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THESIS 2

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 INTRODUCTION:- FACTORS INFLUENCING THE DEVELOPMENT OF HYPOALBUMINEMIA AND ITS OUTCOMES Problem Statement:- In adult humans, albumin is the most abundant plasma protein with a concentration ranging from 35 to 50 g/L. Albumin represents 50% of the total protein content of plasma, with globulins making up most of the rest. It is a single peptide chain of 585 amino acids in a globular structure. The molecular weight of albumin is approximately 66 kDa, and it has a half-life of 21 days. Albumin is exclusively synthesized by the liver, initially a pre-proalbumin and then proalbumin, which in the Golgi apparatus is converted to albumin, which is the final form secreted by the hepatocyte. The synthetic rate is about 10 to 15 grams per day and then secreted into the circulation of which around 40% remains in circulation with a fraction moving from the intravascular to the interstitial space. Factors that stimulate albumin synthesis include the action of hormones such as insulin and growth horm
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THESIS

DR.RAVI KUMAR THESIS    INTRODUCTION:  GLYCEMIC VARIABILITY AND ASSOCIATION AND OUTCOMES WITH URINARY ALBUMIN EXCRETION IN DIABETES MELLITUS PROBLEM STATEMENT: Diabetes mellitus (DM) has long been recognized as a major public health problem for its adverse health impact on individuals and for its economic burden on the health care system and the society at large Patients with Type 2 diabetes often have a long asymptomatic period of hyperglycemia and many have complications at the time of diagnosis. Diabetic Nephropathy is a common consequence of longstanding diabetes mellitus. It is characterized by the presence of large amounts of urinary proteins, mostly albumin. Like other microvascular complications, the pathogenesis of diabetic  nephropathy is related to chronic hyperglycaemia. The laboratory test for early detection of diabetic nephropathy is the measurement of microalbumin in urine (microalbuminuria). There are many conditions causing microalbuminuria but hypertension and diabet
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